The target reticle should go away when SHIFT+F5 is pressed.
Long menus, such as the emote menus and the landmarks menu on the compass, should be limited in height and scrollable. So you don't end up with a menu so long it goes off screen, leaving part of it inaccessible.
The ability to rearrange contact list manually. So for example, you could arrange people you want to quickly see the status of at the top, members of a certain guild together, etc.
The Matis 1h sword currently has no light trail. Makes hitting with one...unrewarding. XD
Thanks for this opportunity.

Small annoyances and disfuctions, especially relating to the user interface, can sometimes be the worst.